So much cheesy goodness, spicy pepperoni flavor and delicious sauce coated noodles, brings this Pepperoni Pizza Spaghetti Casserole together for a hearty meal anytime!

Pepperoni Pizza Spaghetti Casserole Featured Image

Why You’ll Love This Pepperoni Pizza Spaghetti Casserole

  • A family favorite, it will quickly become part of your favorite meal rotation!
  • Easily customizable but super flavorful on it’s own – see our suggestions for add in’s below.
  • So much melty cheese goodness, you just can’t go wrong!
  • Stores in the refrigerator for up to 7 days and in the freezer for up to 6 months (see storage tips below).

This recipe can be made with 5 ingredients or less. I usually add some garlic and onion to the tomato sauce, a little salt & pepper to taste, but those ingredients are not necessary to make this taste great on it’s own.

It also depends on if you use spaghetti sauce or regular tomato sauce. If I use spaghetti sauce, I purchase one with flavors already in it like a 3+ cheese, or Italian Seasoning. We also use white sauce sometimes in conjunction or separately in this casserole. No matter which you use, it’s incredibly awesome.

What 5 Ingredients make up this Pepperoni Pizza Spaghetti Casserole

  • spaghetti noodles
  • pasta sauce
  • sour cream
  • mozzarella cheese
  • pepperoni
Pepperoni Pizza Spaghetti Casserole

Add In’s for this Pepperoni Pizza Spaghetti Casserole

  • fresh herbs
  • try different types of cheese, not just traditional pizza cheese
  • if you like things like jalapenos or bell peppers, add those to the casserole
  • freshly diced onions, garlic, etc.
  • parmesan cheese

How to store this Pepperoni Pizza Spaghetti Casserole and Leftovers

Our family is big (seven of us), so we make a huge casserole dish full. Not just a 9×13 but I’ve adapted this recipe to fit a regular 9×13 so you can make it for your smaller family.

You can also double the recipe and make as much as we did. Fit in 2 casserole dishes and you have one you can freeze or give to a friend!

Freezer Instructions

If you have leftovers, store individual servings in a freezer safe airtight storage container for up to six months. Remove from freezer and microwave for 2 1/2 minutes, stirring and then return to microwave for another 2 1/2 minutes or so. After 5 minutes, add 1 minute increments until hot throughout.

If you prepare an extra casserole, it can go from freezer to oven. Bake at 350 for approximately 45 minutes. Check the center and then add 10 minute increments until completely heated through.

Refrigeration Instructions

This casserole refrigerates well for up to 7 days. Reheat in the microwave for a quick and easy lunch or dinner.

Pepperoni Pizza Spaghetti Casserole

Making this recipe

Pepperoni Pizza Spaghetti Casserole Featured Image

Pepperoni Pizza Spaghetti Casserole

Nicole Cook
This Pepperoni Pizza Spaghetti Casserole is a family favorite that’s easy and delicious and quick to throw together.
4.75 from 8 votes
Prep Time 15 minutes
Cook Time 15 minutes
Total Time 30 minutes
Course Main Dish
Cuisine American
Servings 12
Calories 225 kcal


  • 8 ounces spaghetti noodles cooked
  • 24 ounces pasta sauce
  • 8 ounces sour cream
  • 2 cups mozzarella cheese more or less depending on taste
  • 1 cup pepperoni more to taste


  • Preheat oven to 350.
  • If you haven’t already cooked your pasta, do that now. Once it’s cooked and drained, put it in a 9×13 glass casserole dish.
  • In a bowl, combine the spaghetti sauce and the sour cream. If you are wanting this to be 5 ingredients or less, stop here. But if you want to add some garlic, onion, spices & seasonings – add to the spaghetti sauce/sour cream combo now. We also add about ¼ cup of Parmesan cheese.
  • Mix the sauce into the noodles in the dish.
  • Cover with half the Mozzarella cheese you are planning to use. (we use a LOT of cheese)
  • Layer the entire top of the casserole with pepperoni slices.
  • Sprinkle the remaining cheese across the top.
  • Put in the oven for 10-15 minutes or until cheese is melted. Serve immediately.

For Freezing:

  • If you make this to freeze, prepare as directed but DO NOT put in the oven. Cover and freeze. When ready to bake, remove from the freezer and allow to sit at room temperature for 30-45 minutes uncovered.
  • Put in the oven at 350 degrees for 30-45 minutes.


Calories: 225kcalCarbohydrates: 19gProtein: 10gFat: 13gSaturated Fat: 6gPolyunsaturated Fat: 1gMonounsaturated Fat: 4gTrans Fat: 0.2gCholesterol: 35mgSodium: 542mgPotassium: 274mgFiber: 1gSugar: 3gVitamin A: 489IUVitamin C: 4mgCalcium: 127mgIron: 1mg
Keyword easy casserole recipes
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  1. We’re going to make this for dinner tonight. Thanks for the recipe. Quick question – how much (dry) noodles do I cook to make 8 oz. cooked noodles?

    1. Its the same- 8 oz. You just need to cook it before putting it in the casserole dish, which is why it says cooked. I hope you enjoy it! It’s so good and a real favorite around here.

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